Massive factor-VIII infusion in Haemophiliac with factor-VIII inhibitor, high responder
نویسندگان
چکیده
منابع مشابه
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
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patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhib...
متن کاملAcquired factor VIII inhibitor.
PERSISTENT or uncontrolled bleeding is one of the most feared consequences of any surgical procedure. Numerous factors can contribute to its etiology. Among these, both inherited and acquired disorders of coagulation and/or thrombocyte function need to be taken into account. Acquired hemophilia can be caused by antibodies to coagulation factors. Antibodies can arise in hemophilic or nonhemophil...
متن کاملHigh-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors.
Hemophilia A in its severe form is a life-threatening hemorrhagic disease that is caused by mutations in the factor VIII (FVIII) gene (symbol F8). About 25% of patients who receive replacement therapy develop neutralizing antibodies that inhibit the function of substituted FVIII. Long-term application of high doses of FVIII has evolved as an effective therapy to eradicate the antibodies and to ...
متن کاملRepression of Factor VIII Inhibitor Development with Apoptotic Factor VIII-expressing Embryonic Stem Cells
Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to prevent the development of fVIII inhibitors. Murine ES cells integrated with the human F8 gene were differentiated into embryoid bodies, dissoci...
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ژورنال
عنوان ژورنال: Haemophilia
سال: 2009
ISSN: 1351-8216,1365-2516
DOI: 10.1111/j.1365-2516.2010.02266.x